%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Jessica L. Reed, Enrico D’Ambrosio, Stefano Marenco, Gianluca Ursini, Amanda B. Zheutlin, Giuseppe Blasi, Barbara E. Spencer, Raffaella Romano, Jesse Hochheiser, Ann Reifman, Justin Sturm, Karen F. Berman, Alessandro Bertolino, Daniel R. Weinberger, Joseph H. Callicott
Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref002)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref007)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref008)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref009)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref013)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref014)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref016)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref017)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref018)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref019)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref020)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref021)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref022)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref023)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref024)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref022)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref025)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref026)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref027)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref028)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref029)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref030)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref031)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref032)>>
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref034)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref035)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref039)>>
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref040)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref041)>>
endobj
51 0 obj
<>/Border[0 0 0]/A 52 0 R>>
endobj
52 0 obj
<>
endobj
14 0 obj
[53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R]
endobj
53 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 680.2299 m
199.9998 680.2299 l
199.9998 680.73 l
575.9997 680.73 l
f*
0.83 0.64 0.02 0 k
530.4189 588.926 m
535.1811 588.926 l
h
f*
471.7417 562.9039 m
476.5039 562.9039 l
h
f*
359.2063 549.9213 m
363.9118 549.9213 l
h
f*
442.148 549.9213 m
446.9102 549.9213 l
h
f*
268.8945 536.9386 m
273.6567 536.9386 l
h
f*
432.5669 536.9386 m
437.2724 536.9386 l
h
f*
445.2661 523.8992 m
450.0283 523.8992 l
h
f*
221.8961 497.9339 m
226.6583 497.9339 l
h
f*
379.2189 484.8945 m
383.9811 484.8945 l
h
f*
389.1402 484.8945 m
393.9024 484.8945 l
h
f*
504.1134 471.9118 m
513.6378 471.9118 l
h
f*
518.7969 471.9118 m
528.3213 471.9118 l
h
f*
361.0205 445.9465 m
370.5449 445.9465 l
h
f*
375.7039 445.9465 m
385.2283 445.9465 l
h
f*
308.2961 419.9244 m
317.7638 419.9244 l
h
f*
536.6551 406.9417 m
546.1795 406.9417 l
h
f*
307.8425 367.937 m
317.3102 367.937 l
h
f*
451.0488 341.915 m
460.5732 341.915 l
h
f*
287.7165 328.9323 m
297.2409 328.9323 l
h
f*
455.2441 328.9323 m
464.7685 328.9323 l
h
f*
203.4142 289.9276 m
212.9386 289.9276 l
h
f*
218.0976 289.9276 m
227.622 289.9276 l
h
f*
222.0094 263.9055 m
231.5339 263.9055 l
h
f*
246.0472 211.9181 m
255.5717 211.9181 l
h
f*
260.7307 211.9181 m
270.2551 211.9181 l
h
f*
260.1071 198.9354 m
269.5748 198.9354 l
h
f*
361.8142 198.9354 m
371.2819 198.9354 l
h
f*
429.789 198.9354 m
439.3134 198.9354 l
h
f*
524.6929 198.9354 m
534.2173 198.9354 l
h
f*
338.9102 172.9134 m
348.4346 172.9134 l
h
f*
346.6205 107.9433 m
356.0882 107.9433 l
h
f*
361.3039 107.9433 m
370.7717 107.9433 l
h
f*
318.8976 94.9039 m
328.422 94.9039 l
h
f*
333.5811 94.9039 m
343.1055 94.9039 l
h
f*
382.6772 81.9213 m
392.2016 81.9213 l
h
f*
397.3606 81.9213 m
406.885 81.9213 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(environmental)Tj
6.4211 0 Td
(exposure)Tj
4.2908 0 Td
(could)Tj
2.578 0 Td
(mediate,)Tj
4.0103 0 Td
(at)Tj
1.0503 0 Td
(least)Tj
2.3035 0 Td
(partially,)Tj
3.8909 0 Td
(increased)Tj
4.5056 0 Td
(risk)Tj
1.7545 0 Td
(for)Tj
1.3785 0 Td
(psychiatric)Tj
4.8875 0 Td
(ill-)Tj
-37.071 -1.474 Td
(ness)Tj
2.3094 0 Td
(in)Tj
0.9847 0 Td
(urban)Tj
2.7451 0 Td
(environments)Tj
6.1586 0 Td
(via)Tj
1.48 0 Td
(dopamine)Tj
4.5533 0 Td
(genes)Tj
2.9123 0 Td
(expressed)Tj
4.786 0 Td
(into)Tj
1.8082 0 Td
(adulthood.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 619.9937 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 602.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(As)Tj
1.2642 0 Td
(people)Tj
2.8516 0 Td
(live)Tj
1.6158 0 Td
(in)Tj
1.0318 0 Td
(ever-denser)Tj
4.9039 0 Td
(population)Tj
4.5864 0 Td
(centers,)Tj
3.2995 0 Td
(the)Tj
1.4683 0 Td
(implications)Tj
5.1761 0 Td
(of)Tj
1.0148 0 Td
(urbanization)Tj
5.3404 0 Td
(for)Tj
1.389 0 Td
(health)Tj
-33.9418 -1.2982 Td
(and)Tj
1.7291 0 Td
(well-being)Tj
4.3823 0 Td
(remain)Tj
3.0841 0 Td
(unclear.)Tj
3.4185 0 Td
(Urban)Tj
2.8177 0 Td
(environments)Tj
5.7939 0 Td
(carry)Tj
2.2734 0 Td
(both)Tj
2.058 0 Td
(benefits)Tj
3.3391 0 Td
(and)Tj
1.7292 0 Td
(risks)Tj
2.0749 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(Urban)Tj
-34.3046 -1.2983 Td
(upbringing)Tj
4.7054 0 Td
(and)Tj
1.7292 0 Td
(urban)Tj
2.6078 0 Td
(living)Tj
2.4718 0 Td
(\(urbanicity\))Tj
5.7826 0 Td
(offer)Tj
2.0977 0 Td
(benefits)Tj
3.3335 0 Td
(from)Tj
2.2053 0 Td
(increased)Tj
4.0025 0 Td
(productivity)Tj
5.1364 0 Td
(and)Tj
-34.0722 -1.3039 Td
(prosperity,)Tj
4.5354 0 Td
(higher)Tj
2.8006 0 Td
(wages,)Tj
2.8119 0 Td
(and)Tj
1.7291 0 Td
(increased)Tj
4.0025 0 Td
(access)Tj
2.6476 0 Td
(to)Tj
1.0261 0 Td
(cultural)Tj
3.2939 0 Td
(resources)Tj
3.9911 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(However,)Tj
4.0762 0 Td
(city)Tj
1.6668 0 Td
(life)Tj
1.44 0 Td
(car-)Tj
-35.6199 -1.2983 Td
(ries)Tj
1.644 0 Td
(disadvantages)Tj
5.7543 0 Td
(like)Tj
1.6555 0 Td
(increased)Tj
3.9968 0 Td
(crime)Tj
2.5285 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(],)Tj
1.5987 0 Td
(over-population)Tj
6.6954 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(],)Tj
1.6044 0 Td
(psychiatric)Tj
4.5637 0 Td
(symptoms)Tj
4.3597 0 Td
(from)Tj
-34.401 -1.2982 Td
(crowd)Tj
2.7325 0 Td
(exposure)Tj
3.8154 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.6044 0 Td
(and)Tj
1.7292 0 Td
(demanding)Tj
4.7791 0 Td
(social)Tj
2.4605 0 Td
(environments)Tj
5.794 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(Urbanicity,)Tj
4.7508 0 Td
(related)Tj
2.9481 0 Td
(to)Tj
1.0261 0 Td
(poorer)Tj
-33.2388 -1.3039 Td
(mental)Tj
2.9876 0 Td
(health,)Tj
2.9027 0 Td
(increases)Tj
3.8324 0 Td
(risk)Tj
1.7178 0 Td
(for)Tj
1.389 0 Td
(anxiety)Tj
3.1067 0 Td
(and)Tj
1.7348 0 Td
(mood)Tj
2.5795 0 Td
(disorders)Tj
3.9345 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(],)Tj
1.6044 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(doubling)Tj
3.8211 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(lifetime)Tj
-34.4747 -1.2983 Td
(prevalence)Tj
4.4843 0 Td
(of)Tj
1.0148 0 Td
(schizophrenia)Tj
5.811 0 Td
(with)Tj
1.9956 0 Td
(an)Tj
1.2019 0 Td
(associated)Tj
4.2576 0 Td
(population)Tj
4.5921 0 Td
(relative)Tj
3.1351 0 Td
(risk)Tj
1.7178 0 Td
(larger)Tj
2.5341 0 Td
(than)Tj
2.0239 0 Td
(family)Tj
2.7326 0 Td
(his-)Tj
-35.5008 -1.2983 Td
(tory)Tj
1.8481 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.6044 0 Td
(Known)Tj
3.1805 0 Td
(for)Tj
1.3889 0 Td
(some)Tj
2.3301 0 Td
(time,)Tj
2.2507 0 Td
(environment)Tj
5.4312 0 Td
(and)Tj
1.7291 0 Td
(gene-environment)Tj
7.6421 0 Td
(\(GxE\))Tj
2.6532 0 Td
(interactions)Tj
4.9663 0 Td
(alter)Tj
-35.0246 -1.3039 Td
(brain)Tj
2.347 0 Td
(development)Tj
5.4085 0 Td
(in)Tj
1.0375 0 Td
(experimental)Tj
5.4595 0 Td
(animals)Tj
3.3278 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
2.5965 0 Td
(These)Tj
2.5625 0 Td
(effects)Tj
2.7269 0 Td
(have)Tj
2.0637 0 Td
(ramifications)Tj
5.5048 0 Td
(within)Tj
2.812 0 Td
(the)Tj
-35.8467 -1.2983 Td
(brain)Tj
2.347 0 Td
(including)Tj
4.0422 0 Td
(neurogenesis,)Tj
5.6749 0 Td
(neurotransmission,)Tj
7.9653 0 Td
(brain)Tj
2.3471 0 Td
(size,)Tj
1.9105 0 Td
(and)Tj
1.7292 0 Td
(cognition)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
-28.8735 -1.2982 Td
(Environmental)Tj
6.2588 0 Td
(factors)Tj
2.9027 0 Td
(likely)Tj
2.3527 0 Td
(influence)Tj
3.9175 0 Td
(heritable)Tj
3.719 0 Td
(complex)Tj
3.6227 0 Td
(human)Tj
3.0784 0 Td
(traits,)Tj
2.4774 0 Td
(from)Tj
2.2054 0 Td
(temperament)Tj
-31.7308 -1.2983 Td
(and)Tj
1.7291 0 Td
(cognition)Tj
4.0535 0 Td
(to)Tj
1.0261 0 Td
(psychiatric)Tj
4.5638 0 Td
(illness)Tj
2.6759 0 Td
(risk)Tj
1.7121 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
3.5489 0 Td
(For)Tj
1.6214 0 Td
(example,)Tj
3.7758 0 Td
(allelic)Tj
2.5058 0 Td
(variation)Tj
3.804 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(serotonin)Tj
-33.5223 -1.3039 Td
(transporter)Tj
4.7224 0 Td
(gene)Tj
/F10 1 Tf
2.0807 0 Td
[()8()14()]TJ
/F6 1 Tf
3.4072 0 Td
(increases)Tj
3.8324 0 Td
(susceptibility)Tj
5.4368 0 Td
(to)Tj
1.0261 0 Td
(depression)Tj
4.5298 0 Td
(in)Tj
1.0375 0 Td
(adults)Tj
2.6135 0 Td
(exposed)Tj
3.4469 0 Td
(to)Tj
1.0205 0 Td
(stress)Tj
-33.1538 -1.2983 Td
(during)Tj
2.9253 0 Td
(early)Tj
2.1486 0 Td
(development)Tj
5.4142 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.0749 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8211 0 Td
(obstetrical)Tj
4.354 0 Td
(complications)Tj
5.845 0 Td
(interact)Tj
3.2825 0 Td
(with)Tj
1.9955 0 Td
(genes)Tj
-32.9723 -1.2982 Td
(implicated)Tj
4.4446 0 Td
(in)Tj
1.0319 0 Td
(hypoxic-ischemic)Tj
7.2509 0 Td
(tissue)Tj
2.4548 0 Td
(injury)Tj
2.6476 0 Td
(increasing)Tj
4.3313 0 Td
(risk)Tj
1.7121 0 Td
(for)Tj
1.389 0 Td
(adult)Tj
2.2506 0 Td
(schizophrenia)Tj
5.811 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.075 0 Td
(Neu-)Tj
-35.3988 -1.3039 Td
(roimaging)Tj
4.3596 0 Td
(suggests)Tj
3.4753 0 Td
(that)Tj
1.7744 0 Td
(the)Tj
1.4627 0 Td
(human)Tj
3.0727 0 Td
(brain)Tj
2.3414 0 Td
(is)Tj
0.8391 0 Td
(sensitive)Tj
3.617 0 Td
(to)Tj
1.0204 0 Td
(environmental)Tj
6.1058 0 Td
(influences,)Tj
4.4958 0 Td
(as)Tj
1.0091 0 Td
(evidenced)Tj
-33.5733 -1.2983 Td
(by)Tj
1.1792 0 Td
(London)Tj
3.3958 0 Td
(taxi)Tj
1.6895 0 Td
(drivers)Tj
2.9933 0 Td
(who)Tj
1.9389 0 Td
(showed)Tj
3.2542 0 Td
(increased)Tj
3.9968 0 Td
(hippocampal)Tj
5.4312 0 Td
(size)Tj
1.6837 0 Td
(attributable)Tj
4.8359 0 Td
(to)Tj
1.0261 0 Td
(intensive)Tj
3.8098 0 Td
(spa-)Tj
-35.2344 -1.2983 Td
(tial)Tj
1.4626 0 Td
(navigational)Tj
5.1194 0 Td
(demands)Tj
3.8607 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
2.0693 0 Td
(Using)Tj
2.5965 0 Td
(fMRI)Tj
2.3584 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6463 0 Td
(social-stress)Tj
4.9833 0 Td
(task,)Tj
2.0353 0 Td
(Lederbogen)Tj
4.9492 0 Td
(and)Tj
1.7292 0 Td
(colleagues)Tj
-33.5393 -1.3039 Td
(\(2011\))Tj
2.8006 0 Td
(found)Tj
2.6192 0 Td
(that)Tj
1.7801 0 Td
(childhood)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(adult)Tj
2.2564 0 Td
(urbanicity)Tj
4.32 0 Td
(were)Tj
2.1203 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(regional)Tj
3.4866 0 Td
(activation)Tj
4.1499 0 Td
(and)Tj
-35.7956 -1.2983 Td
(functional)Tj
4.3086 0 Td
(coupling)Tj
3.719 0 Td
(within)Tj
2.8176 0 Td
(the)Tj
1.4684 0 Td
(limbic)Tj
2.7496 0 Td
(system)Tj
2.9366 0 Td
(of)Tj
1.0148 0 Td
(healthy)Tj
3.1351 0 Td
(adults)Tj
2.6136 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7858 0 Td
(same)Tj
2.2564 0 Td
(group)Tj
2.6078 0 Td
(linked)Tj
-33.4882 -1.2982 Td
(urbanicity)Tj
4.3199 0 Td
(to)Tj
1.0262 0 Td
(NPSR1)Tj
3.084 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
1.8539 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(decreased)Tj
4.1329 0 Td
(gray)Tj
1.9446 0 Td
(matter)Tj
2.8686 0 Td
(volume)Tj
3.1975 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.0749 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
1.4683 0 Td
(case)Tj
1.8652 0 Td
(of)Tj
1.0148 0 Td
(schizophre-)Tj
-32.7172 -1.2983 Td
(nia,)Tj
1.6951 0 Td
(a)Tj
0.6519 0 Td
(heritable)Tj
3.7191 0 Td
(brain)Tj
2.347 0 Td
(disorder)Tj
3.5773 0 Td
(closely)Tj
2.88 0 Td
(tied)Tj
1.7405 0 Td
(to)Tj
1.0261 0 Td
(dopamine,)Tj
4.4901 0 Td
(studies)Tj
2.982 0 Td
(have)Tj
2.0636 0 Td
(shown)Tj
2.846 0 Td
(increased)Tj
4.0025 0 Td
(relative)Tj
-34.0212 -1.3039 Td
(risk)Tj
1.7121 0 Td
(for)Tj
1.3889 0 Td
(those)Tj
2.3358 0 Td
(raised)Tj
2.6078 0 Td
(in)Tj
1.0318 0 Td
(an)Tj
1.2019 0 Td
(urban)Tj
2.6135 0 Td
(environment)Tj
5.4312 0 Td
(and)Tj
1.7291 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(development)Tj
5.4085 0 Td
(to)Tj
1.0261 0 Td
(age)Tj
1.542 0 Td
(15)Tj
1.1736 0 Td
(years)Tj
-35.4555 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.5432 0 Td
(Here,)Tj
2.4321 0 Td
(we)Tj
1.3267 0 Td
(predicted)Tj
4.0024 0 Td
(that)Tj
1.7745 0 Td
(cognitive)Tj
3.8778 0 Td
(neural)Tj
2.7723 0 Td
(function)Tj
3.6283 0 Td
(measured)Tj
4.1102 0 Td
(by)Tj
1.1792 0 Td
(our)Tj
1.6271 0 Td
(fMRI)Tj
2.3584 0 Td
(task)Tj
1.8141 0 Td
(and)Tj
-34.4463 -1.2982 Td
(without)Tj
3.3278 0 Td
(explicit)Tj
3.1294 0 Td
(social)Tj
2.4605 0 Td
(stress,)Tj
2.6192 0 Td
(would)Tj
2.7156 0 Td
(be)Tj
1.1451 0 Td
(sensitive)Tj
3.6284 0 Td
(to)Tj
1.0261 0 Td
(urbanicity)Tj
4.32 0 Td
(as)Tj
1.0148 0 Td
(suggested)Tj
4.0705 0 Td
(by)Tj
1.1792 0 Td
(prior)Tj
2.2564 0 Td
(MRI)Tj
2.0749 0 Td
(find-)Tj
-34.9679 -1.304 Td
(ings)Tj
1.8595 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
-0.6633 -1.2982 Td
(In)Tj
1.1111 0 Td
(addition)Tj
3.6 0 Td
(to)Tj
1.0205 0 Td
(fMRI)Tj
2.3641 0 Td
(effects)Tj
2.7269 0 Td
(of)Tj
1.0148 0 Td
(urbanicity,)Tj
4.5467 0 Td
(we)Tj
1.3266 0 Td
(sought)Tj
2.9027 0 Td
(GxE)Tj
1.9729 0 Td
(interaction)Tj
4.6091 0 Td
(between)Tj
3.5263 0 Td
(urbanicity)Tj
-31.9179 -1.2983 Td
(and)Tj
1.7234 0 Td
(dopamine)Tj
4.2519 0 Td
(genes.)Tj
2.6646 0 Td
(Dopamine)Tj
4.4617 0 Td
(genes)Tj
2.4321 0 Td
(represent)Tj
3.9515 0 Td
(critical)Tj
2.9423 0 Td
(links)Tj
2.1317 0 Td
(to)Tj
1.0204 0 Td
(cortical)Tj
3.1805 0 Td
(dopamine)Tj
4.2576 0 Td
(and)Tj
1.7234 0 Td
(its)Tj
1.1396 0 Td
(fun-)Tj
-35.8807 -1.3039 Td
(damental)Tj
3.9514 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0318 0 Td
(DLPFC)Tj
3.2485 0 Td
(function)Tj
3.6283 0 Td
(with)Tj
1.9956 0 Td
(ties)Tj
1.5704 0 Td
(to)Tj
1.0261 0 Td
(our)Tj
1.6271 0 Td
(fMRI)Tj
2.3584 0 Td
(phenotype.)Tj
4.6658 0 Td
(Additionally,)Tj
5.4538 0 Td
(stress)Tj
2.3981 0 Td
(affects)Tj
-34.7241 -1.2983 Td
(dopamine)Tj
4.2632 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(],)Tj
3.5433 0 Td
(and)Tj
1.7348 0 Td
(dopamine)Tj
4.2633 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.1203 0 Td
(linked)Tj
2.7326 0 Td
(with)Tj
1.9956 0 Td
(environmental)Tj
6.1114 0 Td
(exposures)Tj
4.1783 0 Td
(like)Tj
1.6554 0 Td
(early)Tj
-34.1402 -1.2982 Td
(maternal)Tj
3.7927 0 Td
(care)Tj
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(],)Tj
2.075 0 Td
(childhood)Tj
4.2802 0 Td
(adversity)Tj
3.8155 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(],)Tj
2.0749 0 Td
(acute)Tj
2.3244 0 Td
(stress)Tj
2.3981 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7348 0 Td
(chronic)Tj
3.2882 0 Td
(stress)Tj
2.3924 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
2.0806 0 Td
(While)Tj
-34.2082 -1.3039 Td
(no)Tj
1.2755 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.532 0 Td
(dopamine)Tj
4.2633 0 Td
(and)Tj
1.7291 0 Td
(urbanicity,)Tj
4.5467 0 Td
(urbanicity)Tj
4.3143 0 Td
(and)Tj
1.7348 0 Td
(stress)Tj
2.3925 0 Td
(induces)Tj
3.2995 0 Td
(changes)Tj
3.4072 0 Td
(in)Tj
-35.121 -1.2983 Td
(cortisol,)Tj
3.4242 0 Td
(itself)Tj
2.1033 0 Td
(linked)Tj
2.7326 0 Td
(to)Tj
1.0261 0 Td
(dopamine)Tj
4.2633 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
2.0749 0 Td
(Three)Tj
2.5795 0 Td
(dopamine)Tj
4.2633 0 Td
(genes)Tj
2.4435 0 Td
(that)Tj
1.7801 0 Td
(are)Tj
1.4457 0 Td
(expressed)Tj
4.0932 0 Td
(in)Tj
1.0374 0 Td
(prefrontal)Tj
-33.2671 -1.2983 Td
(cortex)Tj
2.7099 0 Td
(and)Tj
1.7291 0 Td
(that)Tj
1.7745 0 Td
(are)Tj
1.4513 0 Td
(important)Tj
4.2803 0 Td
(mediators)Tj
4.2292 0 Td
(of)Tj
1.0148 0 Td
(prefrontal)Tj
4.2293 0 Td
(function)Tj
3.6283 0 Td
(were)Tj
2.1203 0 Td
(chosencatechol-o-)Tj
-27.167 -1.2982 Td
(methyl-transferase)Tj
7.6534 0 Td
(gene)Tj
2.0807 0 Td
(\()Tj
/F10 1 Tf
[()-6()13( )-2(\n)]TJ
/F6 1 Tf
(,)Tj
3.8834 0 Td
(dopamine)Tj
4.2633 0 Td
(receptor)Tj
3.5546 0 Td
(D1)Tj
1.4343 0 Td
(\()Tj
/F10 1 Tf
[()13(\r)]TJ
/F6 1 Tf
(\),)Tj
3.5717 0 Td
(and)Tj
1.7291 0 Td
(dopamine)Tj
4.2633 0 Td
(receptor)Tj
-32.4338 -1.304 Td
(D2)Tj
1.4286 0 Td
(\()Tj
/F10 1 Tf
[()13()]TJ
/F6 1 Tf
(\),)Tj
3.5716 0 Td
(specifically)Tj
4.5751 0 Td
(polymorphisms)Tj
/F10 1 Tf
6.497 0 Td
[()-6()13( )]TJ
/F6 1 Tf
2.9934 0 Td
(rs4680)Tj
2.8573 0 Td
(\(Val)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 436.3653 139.4645 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(158)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 447.0803 134.9858 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Met\),)Tj
/F10 1 Tf
2.398 0 Td
[()13(\r)]TJ
/F6 1 Tf
2.6646 0 Td
(rs4532)Tj
2.8573 0 Td
(\(-48)Tj
1.8595 0 Td
(A/G)Tj
-34.486 -1.2982 Td
(dDel\),)Tj
2.7156 0 Td
(and)Tj
/F10 1 Tf
1.7348 0 Td
[()13()]TJ
/F6 1 Tf
2.6645 0 Td
(rs1076560.)Tj
4.5071 0 Td
(Prior)Tj
2.2961 0 Td
(reports)Tj
3.067 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.6577 0 Td
(meta-analysis)Tj
5.6521 0 Td
(have)Tj
2.058 0 Td
(linked)Tj
/F10 1 Tf
2.7269 0 Td
[()-6()13( )]TJ
/F6 1 Tf
2.999 0 Td
(Val)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 541.8708 126.4251 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(158)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 552.5291 122.0031 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Met)Tj
-35.2514 -1.2982 Td
(\(rs4680\))Tj
3.532 0 Td
(to)Tj
1.0261 0 Td
(DLPFC)Tj
3.2428 0 Td
(fMRI)Tj
2.3641 0 Td
(activation)Tj
4.1556 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
(].)Tj
/F10 1 Tf
3.5432 0 Td
[()13(\r)]TJ
/F6 1 Tf
2.6646 0 Td
(and)Tj
/F10 1 Tf
1.7291 0 Td
[()13()]TJ
/F6 1 Tf
2.6646 0 Td
(influence)Tj
3.9174 0 Td
(cortical)Tj
3.1918 0 Td
(DA)Tj
1.6384 0 Td
(synaptic)Tj
-33.6697 -1.3039 Td
(activity)Tj
3.1181 0 Td
(and)Tj
1.7291 0 Td
(neuronal)Tj
3.8268 0 Td
(tuning)Tj
2.8743 0 Td
([)Tj
0.83 0.64 0.02 0 k
(35)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(].)Tj
/F10 1 Tf
3.5489 0 Td
[()13(\r)]TJ
/F6 1 Tf
2.6646 0 Td
(rs4532)Tj
2.8516 0 Td
(is)Tj
0.8504 0 Td
(in)Tj
1.0318 0 Td
(strong)Tj
2.7723 0 Td
(LD)Tj
1.4967 0 Td
(across)Tj
2.6759 0 Td
(the)Tj
1.4683 0 Td
(gene)Tj
2.0806 0 Td
(and)Tj
1.7348 0 Td
(DRD1)Tj
-34.7242 -1.2983 Td
(binding)Tj
3.3505 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(tied)Tj
1.7404 0 Td
(to)Tj
1.0262 0 Td
(fMRI)Tj
2.3584 0 Td
(memory)Tj
3.617 0 Td
(tasks)Tj
2.1713 0 Td
([)Tj
0.83 0.64 0.02 0 k
(40)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(].)Tj
3.5433 0 Td
(The)Tj
/F10 1 Tf
1.7858 0 Td
[()13(\r)]TJ
/F6 1 Tf
2.6646 0 Td
(rs4532)Tj
2.8516 0 Td
(allele)Tj
2.2393 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 364.9889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Urbanicity)Tj
4.585 0 Td
(and)Tj
1.8496 0 Td
(dopamine)Tj
4.5355 0 Td
(gene)Tj
2.4024 0 Td
(interacti)Tj
3.4299 0 Td
(ons)Tj
1.8071 0 Td
(on)Tj
1.3111 0 Td
(fMRI)Tj
2.3031 0 Td
(activation)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01951)Tj
4.089 0 Td
(89)Tj
0 g
2.0906 0 Td
(April)Tj
2.1827 0 Td
(10,)Tj
1.5874 0 Td
(2018)Tj
35.1357 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(20)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Funding:)Tj
/F9 1 Tf
3.5716 0 Td
(This)Tj
1.7788 0 Td
(work)Tj
2.0622 0 Td
(was)Tj
1.7008 0 Td
(funded)Tj
2.7922 0 Td
(as)Tj
1.063 0 Td
(part)Tj
1.6795 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-15.5977 -1.3748 Td
(Division)Tj
3.1748 0 Td
(of)Tj
0.9496 0 Td
(Intramural)Tj
4.0819 0 Td
(Research)Tj
3.6993 0 Td
(Program)Tj
3.4795 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-16.3347 -1.3749 Td
(National)Tj
3.2386 0 Td
(Institute)Tj
3.2244 0 Td
(of)Tj
0.9496 0 Td
(Mental)Tj
2.7355 0 Td
(Health)Tj
2.5724 0 Td
(and)Tj
1.5874 0 Td
(the)Tj
-14.3079 -1.3748 Td
(Psychiatr)Tj
3.437 0 Td
(ic)Tj
0.8362 0 Td
(Neuroscience)Tj
5.2583 0 Td
(Group,)Tj
2.7567 0 Td
(Department)Tj
4.5922 0 Td
(of)Tj
-16.8804 -1.3748 Td
(Basic)Tj
2.2039 0 Td
(Medical)Tj
3.0969 0 Td
(Science,)Tj
3.3236 0 Td
(Neurosci)Tj
3.2953 0 Td
(ence)Tj
1.963 0 Td
(and)Tj
1.5875 0 Td
(Sense)Tj
-15.4702 -1.3748 Td
(Organs)Tj
2.9055 0 Td
(of)Tj
0.9496 0 Td
(University)Tj
3.9118 0 Td
(of)Tj
0.9497 0 Td
(Bari)Tj
1.6653 0 Td
(Aldo)Tj
1.8851 0 Td
(Moro.)Tj
2.452 0 Td
(The)Tj
-14.719 -1.3748 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6087 0 Td
(in)Tj
0.8929 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.8984 0 Td
(data)Tj
1.793 0 Td
(collection)Tj
-15.2576 -1.3748 Td
(and)Tj
1.5874 0 Td
(analysis,)Tj
3.4087 0 Td
(decision)Tj
3.2953 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1464 0 Td
(or)Tj
0.9993 0 Td
(preparation)Tj
4.4362 0 Td
(of)Tj
-17.8229 -1.3748 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F8 1 Tf
-1.3677 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
endstream
endobj
88 0 obj
<>stream
BT
10.3394 69.591 Td
(exist.)Tj
ET
Q
endstream
endobj
89 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 92 0 R/Contents 93 0 R/TrimBox[0 0 612 792]>>
endobj
92 0 obj
[94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R]
endobj
94 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref042)>>
endobj
95 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref043)>>
endobj
96 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref044)>>
endobj
97 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref046)>>
endobj
98 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref047)>>
endobj
99 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref048)>>
endobj
100 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.t001)>>
endobj
101 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref049)>>
endobj
102 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.ref050)>>
endobj
103 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.s001)>>
endobj
104 0 obj
<>/Border[0 0 0]/Dest(Rpone.0195189.s001)>>
endobj
105 0 obj
<>/Border[0 0 0]/Dest(Lpone.0195189.t001)>>
endobj
106 0 obj
<>/Border[0 0 0]/A 108 0 R>>
endobj
108 0 obj
<>
endobj
107 0 obj
<>/Border[0 0 0]/A 109 0 R>>
endobj
109 0 obj
<>
endobj
93 0 obj
[110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R]
endobj
110 0 obj
<>stream
q
0.83 0.64 0.02 0 k
278.022 693.2976 m
287.5465 693.2976 l
h
f*
292.7055 693.2976 m
302.2299 693.2976 l
h
f*
337.8898 680.315 m
347.4142 680.315 l
h
f*
352.5732 680.315 m
362.0976 680.315 l
h
f*
540 602.3055 m
549.5244 602.3055 l
h
f*
554.6835 602.3055 m
564.2079 602.3055 l
h
f*
463.0677 486.3118 m
492.2646 486.3118 l
h
f*
535.4646 460.3465 m
544.989 460.3465 l
h
f*
550.148 460.3465 m
559.6724 460.3465 l
h
f*
393.2787 395.3197 m
419.6409 395.3197 l
h
f*
519.4772 382.337 m
545.8394 382.337 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(fMRI)Tj
2.3641 0 Td
(measures)Tj
3.9402 0 Td
(of)Tj
1.0147 0 Td
(working)Tj
3.5603 0 Td
(memory)Tj
3.617 0 Td
(tied)Tj
1.7348 0 Td
(to)Tj
1.0262 0 Td
(prefrontal)Tj
4.2235 0 Td
(activation)Tj
4.1556 0 Td
(and)Tj
1.7291 0 Td
(illnesses)Tj
-33.6186 -1.3039 Td
(like)Tj
1.6497 0 Td
(schizophrenia)Tj
5.811 0 Td
([)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(].)Tj
/F10 1 Tf
3.5433 0 Td
[()13()]TJ
/F6 1 Tf
2.6645 0 Td
(rs1076560)Tj
4.286 0 Td
(minor)Tj
2.7326 0 Td
(allele)Tj
2.2393 0 Td
(carriers)Tj
3.2428 0 Td
(showed)Tj
3.2485 0 Td
(altered)Tj
2.948 0 Td
(fMRI)Tj
2.3584 0 Td
(activa-)Tj
-34.7241 -1.2982 Td
(tion)Tj
1.8425 0 Td
(during)Tj
2.9253 0 Td
(our)Tj
1.6271 0 Td
(N-back)Tj
3.1634 0 Td
(WM)Tj
2.0806 0 Td
(task)Tj
1.8085 0 Td
([)Tj
0.83 0.64 0.02 0 k
(44)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(].)Tj
-12.2512 -1.2983 Td
(Given)Tj
2.6305 0 Td
(the)Tj
1.4683 0 Td
(importance)Tj
4.8302 0 Td
(of)Tj
1.0148 0 Td
(dopamine)Tj
4.269 0 Td
(for)Tj
1.3833 0 Td
(optimal)Tj
3.3108 0 Td
(prefrontal)Tj
4.2236 0 Td
(function,)Tj
3.8551 0 Td
(we)Tj
1.3266 0 Td
(hypothesized)Tj
5.4709 0 Td
(that)Tj
-34.9793 -1.2983 Td
(a)Tj
0.6519 0 Td
(main)Tj
2.2904 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(childhood)Tj
4.2803 0 Td
(urbanicity)Tj
4.3199 0 Td
(would)Tj
2.7156 0 Td
(modulate)Tj
4.0025 0 Td
(the)Tj
1.4683 0 Td
(influence)Tj
3.9175 0 Td
(of)Tj
/F10 1 Tf
1.0148 0 Td
[()-6()13( )]TJ
/F6 1 Tf
(,)Tj
/F10 1 Tf
3.2258 0 Td
[()13(\r)]TJ
/F6 1 Tf
(,)Tj
2.8856 0 Td
(and)Tj
/F10 1 Tf
-34.1515 -1.3039 Td
[()13()]TJ
/F6 1 Tf
2.6645 0 Td
(polymorphisms)Tj
6.497 0 Td
(via)Tj
1.3719 0 Td
(interaction.)Tj
4.8359 0 Td
(Based)Tj
2.5455 0 Td
(on)Tj
1.2756 0 Td
(prior)Tj
2.2563 0 Td
(associations)Tj
4.989 0 Td
(between)Tj
3.5263 0 Td
(urban)Tj
2.6078 0 Td
(rearing)Tj
3.1011 0 Td
(and)Tj
-35.6709 -1.2982 Td
(altered)Tj
2.9423 0 Td
(fMRI)Tj
2.3641 0 Td
(activation,)Tj
4.3766 0 Td
(we)Tj
1.3266 0 Td
(tested)Tj
2.5512 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(influence)Tj
3.9175 0 Td
(of)Tj
1.0148 0 Td
(childhood)Tj
4.2803 0 Td
(urbanicity)Tj
4.3199 0 Td
(and)Tj
1.7292 0 Td
(urbanicity-)Tj
-31.6798 -1.2983 Td
(dopamine)Tj
4.2632 0 Td
(gene)Tj
2.0806 0 Td
(interactions)Tj
4.9663 0 Td
(using)Tj
2.3924 0 Td
(fMRI)Tj
2.3641 0 Td
(measures.)Tj
4.1669 0 Td
(Specifically,)Tj
4.9096 0 Td
(the)Tj
1.4683 0 Td
(N-back)Tj
3.1691 0 Td
(fMRI)Tj
2.3641 0 Td
(WM)Tj
2.075 0 Td
(chal-)Tj
-34.2196 -1.3039 Td
(lenge)Tj
2.3243 0 Td
(known)Tj
3.0048 0 Td
(to)Tj
1.0261 0 Td
(activate)Tj
3.2541 0 Td
(a)Tj
0.652 0 Td
(network)Tj
3.549 0 Td
(including)Tj
4.0421 0 Td
(dorsolateral)Tj
4.9493 0 Td
(prefrontal)Tj
4.2236 0 Td
(cortex)Tj
2.7099 0 Td
(\(DLPFC\))Tj
3.9231 0 Td
([)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(48)Tj
0 g
(])Tj
-33.6583 -1.2983 Td
(was)Tj
1.6951 0 Td
(used.)Tj
2.2903 0 Td
(We)Tj
1.6044 0 Td
(predicted)Tj
4.0025 0 Td
(that)Tj
1.7802 0 Td
(if)Tj
0.771 0 Td
(gene-urbanicity)Tj
6.531 0 Td
(relationships)Tj
5.3518 0 Td
(existed,)Tj
3.2144 0 Td
(they)Tj
1.9219 0 Td
(would)Tj
2.7099 0 Td
(be)Tj
1.1509 0 Td
(detected)Tj
3.5659 0 Td
(as)Tj
-36.5893 -1.2983 Td
(alterations)Tj
4.4106 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(relationships)Tj
5.3518 0 Td
(of)Tj
1.0148 0 Td
(dopamine)Tj
4.2633 0 Td
(alleles)Tj
2.6022 0 Td
(to)Tj
1.0261 0 Td
(DLPFC)Tj
3.2428 0 Td
(activation.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 535.4078 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F11 1 Tf
-6.4961 -1.5023 Td
(Subjects)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 500.3716 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(As)Tj
1.2642 0 Td
(the)Tj
/F10 1 Tf
1.4683 0 Td
[()-6()13( )]TJ
/F6 1 Tf
2.9991 0 Td
(discovery)Tj
4.0081 0 Td
(sample,)Tj
3.2485 0 Td
(124)Tj
1.6498 0 Td
(unrelated)Tj
4.0195 0 Td
(Caucasian)Tj
4.3143 0 Td
(healthy)Tj
3.1294 0 Td
(volunteers)Tj
4.3823 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(ages)Tj
-35.4838 -1.2982 Td
(of)Tj
1.0147 0 Td
(18)Tj
1.1679 0 Td
(and)Tj
1.7348 0 Td
(55)Tj
1.1679 0 Td
(\(`discovery'\))Tj
5.1306 0 Td
(\(56)Tj
1.5137 0 Td
(males)Tj
2.5059 0 Td
(and)Tj
1.7291 0 Td
(68)Tj
1.1678 0 Td
(females\))Tj
3.5603 0 Td
(were)Tj
2.1203 0 Td
(studied)Tj
3.1521 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(All)Tj
/F10 1 Tf
1.4003 0 Td
[()-6()13( )]TJ
/F6 1 Tf
(,)Tj
/F10 1 Tf
3.2202 0 Td
[()13(\r)]TJ
/F6 1 Tf
(,)Tj
-34.6278 -1.2983 Td
(and)Tj
/F10 1 Tf
1.7291 0 Td
[()13()]TJ
/F6 1 Tf
2.6645 0 Td
(subjects)Tj
3.3789 0 Td
(were)Tj
2.1203 0 Td
(carefully)Tj
3.6397 0 Td
(screened)Tj
3.719 0 Td
(for)Tj
1.389 0 Td
(medical)Tj
3.3618 0 Td
(or)Tj
1.0942 0 Td
(neurological)Tj
5.1874 0 Td
(illness,)Tj
2.9026 0 Td
(substance)Tj
4.1046 0 Td
(abuse)Tj
-35.2911 -1.2982 Td
(or)Tj
1.0941 0 Td
(dependence,)Tj
5.2384 0 Td
(medications)Tj
5.0967 0 Td
(that)Tj
1.7744 0 Td
(could)Tj
2.4548 0 Td
(affect)Tj
2.3755 0 Td
(brain)Tj
2.347 0 Td
(function,)Tj
3.8551 0 Td
(and)Tj
1.7291 0 Td
(psychiatric)Tj
4.5638 0 Td
(illness)Tj
2.6759 0 Td
([)Tj
0.83 0.64 0.02 0 k
(49)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(].)Tj
-33.2048 -1.304 Td
(The)Tj
1.7801 0 Td
(availability)Tj
4.5297 0 Td
(of)Tj
1.0148 0 Td
(fMRI)Tj
2.3641 0 Td
(data,)Tj
2.1373 0 Td
(urbanicity)Tj
4.32 0 Td
(measures)Tj
3.9401 0 Td
(and)Tj
/F10 1 Tf
1.7348 0 Td
[()-6()13( )]TJ
/F6 1 Tf
(,)Tj
/F10 1 Tf
3.2202 0 Td
[()13(\r)]TJ
/F6 1 Tf
(,)Tj
2.8913 0 Td
(and)Tj
/F10 1 Tf
1.7291 0 Td
[()13()]TJ
/F6 1 Tf
2.6645 0 Td
(genotypes)Tj
-32.326 -1.2982 Td
(were)Tj
2.1203 0 Td
(inclusion)Tj
3.9174 0 Td
(criteria.)Tj
3.2995 0 Td
(We)Tj
1.6101 0 Td
(also)Tj
1.7688 0 Td
(tested)Tj
2.5512 0 Td
(two)Tj
1.7121 0 Td
(independent)Tj
/F10 1 Tf
5.2724 0 Td
[()-6()13( )]TJ
/F6 1 Tf
(-urbanicity)Tj
7.4494 0 Td
(replication)Tj
4.524 0 Td
(samples)Tj
-34.2252 -1.2983 Td
(of)Tj
1.0147 0 Td
(unrelated)Tj
4.0195 0 Td
(Caucasian)Tj
4.3144 0 Td
(subjects)Tj
3.3788 0 Td
(selected)Tj
3.3449 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2563 0 Td
(criteria)Tj
3.0784 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
2.2564 0 Td
(methods)Tj
3.685 0 Td
(as)Tj
1.0148 0 Td
(at)Tj
0.9524 0 Td
(dis-)Tj
-35.9827 -1.3039 Td
(covery,)Tj
3.0784 0 Td
(a)Tj
0.6519 0 Td
(U.S.)Tj
1.8879 0 Td
(replication)Tj
4.5184 0 Td
(consisting)Tj
4.2689 0 Td
(of)Tj
1.0148 0 Td
(137)Tj
1.6498 0 Td
(unrelated)Tj
4.0195 0 Td
(subjects)Tj
3.3789 0 Td
(\(70)Tj
1.508 0 Td
(males)Tj
2.5058 0 Td
(and)Tj
1.7291 0 Td
(67)Tj
1.1735 0 Td
(females\))Tj
3.5547 0 Td
(from)Tj
-34.9396 -1.2983 Td
(our)Tj
1.627 0 Td
(ongoing)Tj
3.5263 0 Td
(study)Tj
2.3868 0 Td
(\(`U.S.)Tj
2.4491 0 Td
(replication,')Tj
4.9662 0 Td
(Panel)Tj
2.4322 0 Td
(A)Tj
0.9014 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0374 0 Td
(S1)Tj
1.1736 0 Td
(File)Tj
0 g
(\))Tj
2.0239 0 Td
(and)Tj
1.7291 0 Td
(226)Tj
1.6441 0 Td
(unrelated)Tj
4.0252 0 Td
(subjects)Tj
3.3789 0 Td
(\(99)Tj
1.508 0 Td
(males)Tj
-34.8092 -1.2982 Td
(and)Tj
1.7291 0 Td
(127)Tj
1.6441 0 Td
(females\))Tj
3.5602 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(region)Tj
2.8006 0 Td
(of)Tj
1.0148 0 Td
(Puglia,)Tj
2.948 0 Td
(Italy)Tj
1.99 0 Td
(\(`Italian)Tj
3.3562 0 Td
(replication,')Tj
4.9662 0 Td
(Panel)Tj
2.4265 0 Td
(B)Tj
0.7993 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(S1)Tj
1.1735 0 Td
(File)Tj
0 g
(\).)Tj
2.2507 0 Td
(The)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
35.9997 355.2874 m
575.9997 355.2874 l
575.9997 354.7874 l
35.9997 354.7874 l
f*
124.7621 354.7874 m
124.7621 342.2874 l
124.2621 342.2874 l
124.2621 354.7874 l
f*
124.2621 342.2874 m
35.9997 342.2874 l
35.9997 342.7875 l
124.2621 342.7875 l
f*
225.3325 354.7874 m
225.3325 342.2874 l
224.8325 342.2874 l
224.8325 354.7874 l
f*
224.8325 342.2874 m
124.7621 342.2874 l
124.7621 342.7875 l
224.8325 342.7875 l
f*
325.9029 354.7874 m
325.9029 342.2874 l
325.4029 342.2874 l
325.4029 354.7874 l
f*
325.4029 342.2874 m
225.3325 342.2874 l
225.3325 342.7875 l
325.4029 342.7875 l
f*
426.4733 354.7874 m
426.4733 342.2874 l
425.9733 342.2874 l
425.9733 354.7874 l
f*
425.9733 342.2874 m
325.9029 342.2874 l
325.9029 342.7875 l
425.9733 342.7875 l
f*
527.0437 354.7874 m
527.0437 342.2874 l
526.5437 342.2874 l
526.5437 354.7874 l
f*
526.5437 342.2874 m
426.4733 342.2874 l
426.4733 342.7875 l
526.5437 342.7875 l
f*
575.998 342.2874 m
527.0437 342.2874 l
527.0437 342.7875 l
575.998 342.7875 l
f*
124.7621 342.2874 m
124.7621 329.7875 l
124.2621 329.7875 l
124.2621 342.2874 l
f*
124.2621 329.7875 m
35.9997 329.7875 l
35.9997 330.2875 l
124.2621 330.2875 l
f*
225.3325 342.2874 m
225.3325 329.7875 l
224.8325 329.7875 l
224.8325 342.2874 l
f*
224.8325 329.7875 m
124.7621 329.7875 l
124.7621 330.2875 l
224.8325 330.2875 l
f*
325.9029 342.2874 m
325.9029 329.7875 l
325.4029 329.7875 l
325.4029 342.2874 l
f*
325.4029 329.7875 m
225.3325 329.7875 l
225.3325 330.2875 l
325.4029 330.2875 l
f*
426.4733 342.2874 m
426.4733 329.7875 l
425.9733 329.7875 l
425.9733 342.2874 l
f*
425.9733 329.7875 m
325.9029 329.7875 l
325.9029 330.2875 l
425.9733 330.2875 l
f*
527.0437 342.2874 m
527.0437 329.7875 l
526.5437 329.7875 l
526.5437 342.2874 l
f*
526.5437 329.7875 m
426.4733 329.7875 l
426.4733 330.2875 l
526.5437 330.2875 l
f*
575.998 329.7875 m
527.0437 329.7875 l
527.0437 330.2875 l
575.998 330.2875 l
f*
124.7621 329.7875 m
124.7621 316.7697 l
124.2621 316.7697 l
124.2621 329.7875 l
f*
124.2621 316.7697 m
35.9997 316.7697 l
35.9997 317.2697 l
124.2621 317.2697 l
f*
225.3325 329.7875 m
225.3325 316.7697 l
224.8325 316.7697 l
224.8325 329.7875 l
f*
224.8325 316.7697 m
124.7621 316.7697 l
124.7621 317.2697 l
224.8325 317.2697 l
f*
325.9029 329.7875 m
325.9029 316.7697 l
325.4029 316.7697 l
325.4029 329.7875 l
f*
325.4029 316.7697 m
225.3325 316.7697 l
225.3325 317.2697 l
325.4029 317.2697 l
f*
426.4733 329.7875 m
426.4733 316.7697 l
425.9733 316.7697 l
425.9733 329.7875 l
f*
425.9733 316.7697 m
325.9029 316.7697 l
325.9029 317.2697 l
425.9733 317.2697 l
f*
527.0437 329.7875 m
527.0437 316.7697 l
526.5437 316.7697 l
526.5437 329.7875 l
f*
526.5437 316.7697 m
426.4733 316.7697 l
426.4733 317.2697 l
526.5437 317.2697 l
f*
575.998 316.7697 m
527.0437 316.7697 l
527.0437 317.2697 l
575.998 317.2697 l
f*
124.7621 316.7697 m
124.7621 304.2697 l
124.2621 304.2697 l
124.2621 316.7697 l
f*
124.2621 304.2697 m
35.9997 304.2697 l
35.9997 304.7698 l
124.2621 304.7698 l
f*
225.3325 316.7697 m
225.3325 304.2697 l
224.8325 304.2697 l
224.8325 316.7697 l
f*
224.8325 304.2697 m
124.7621 304.2697 l
124.7621 304.7698 l
224.8325 304.7698 l
f*
325.9029 316.7697 m
325.9029 304.2697 l
325.4029 304.2697 l
325.4029 316.7697 l
f*
325.4029 304.2697 m
225.3325 304.2697 l
225.3325 304.7698 l
325.4029 304.7698 l
f*
426.4733 316.7697 m
426.4733 304.2697 l
425.9733 304.2697 l
425.9733 316.7697 l
f*
425.9733 304.2697 m
325.9029 304.2697 l
325.9029 304.7698 l
425.9733 304.7698 l
f*
527.0437 316.7697 m
527.0437 304.2697 l
526.5437 304.2697 l
526.5437 316.7697 l
f*
526.5437 304.2697 m
426.4733 304.2697 l
426.4733 304.7698 l
526.5437 304.7698 l
f*
575.998 304.2697 m
527.0437 304.2697 l
527.0437 304.7698 l
575.998 304.7698 l
f*
124.7621 304.2697 m
124.7621 291.7698 l
124.2621 291.7698 l
124.2621 304.2697 l
f*
124.2621 291.7698 m
35.9997 291.7698 l
35.9997 292.2698 l
124.2621 292.2698 l
f*
225.3325 304.2697 m
225.3325 291.7698 l
224.8325 291.7698 l
224.8325 304.2697 l
f*
224.8325 291.7698 m
124.7621 291.7698 l
124.7621 292.2698 l
224.8325 292.2698 l
f*
325.9029 304.2697 m
325.9029 291.7698 l
325.4029 291.7698 l
325.4029 304.2697 l
f*
325.4029 291.7698 m
225.3325 291.7698 l
225.3325 292.2698 l
325.4029 292.2698 l
f*
426.4733 304.2697 m
426.4733 291.7698 l
425.9733 291.7698 l
425.9733 304.2697 l
f*
425.9733 291.7698 m
325.9029 291.7698 l
325.9029 292.2698 l
425.9733 292.2698 l
f*
527.0437 304.2697 m
527.0437 291.7698 l
526.5437 291.7698 l
526.5437 304.2697 l
f*
526.5437 291.7698 m
426.4733 291.7698 l
426.4733 292.2698 l
526.5437 292.2698 l
f*
575.998 291.7698 m
527.0437 291.7698 l
527.0437 292.2698 l
575.998 292.2698 l
f*
124.7621 291.7698 m
124.7621 278.752 l
124.2621 278.752 l
124.2621 291.7698 l
f*
124.2621 278.752 m
35.9997 278.752 l
35.9997 279.252 l
124.2621 279.252 l
f*
225.3325 291.7698 m
225.3325 278.752 l
224.8325 278.752 l
224.8325 291.7698 l
f*
224.8325 278.752 m
124.7621 278.752 l
124.7621 279.252 l
224.8325 279.252 l
f*
325.9029 291.7698 m
325.9029 278.752 l
325.4029 278.752 l
325.4029 291.7698 l
f*
325.4029 278.752 m
225.3325 278.752 l
225.3325 279.252 l
325.4029 279.252 l
f*
426.4733 291.7698 m
426.4733 278.752 l
425.9733 278.752 l
425.9733 291.7698 l
f*
425.9733 278.752 m
325.9029 278.752 l
325.9029 279.252 l
425.9733 279.252 l
f*
527.0437 291.7698 m
527.0437 278.752 l
526.5437 278.752 l
526.5437 291.7698 l
f*
526.5437 278.752 m
426.4733 278.752 l
426.4733 279.252 l
526.5437 279.252 l
f*
575.998 278.752 m
527.0437 278.752 l
527.0437 279.252 l
575.998 279.252 l
f*
124.7621 278.752 m
124.7621 266.252 l
124.2621 266.252 l
124.2621 278.752 l
f*
124.2621 266.252 m
35.9997 266.252 l
35.9997 266.7521 l
124.2621 266.7521 l
f*
225.3325 278.752 m
225.3325 266.252 l
224.8325 266.252 l
224.8325 278.752 l
f*
224.8325 266.252 m
124.7621 266.252 l
124.7621 266.7521 l
224.8325 266.7521 l
f*
325.9029 278.752 m
325.9029 266.252 l
325.4029 266.252 l
325.4029 278.752 l
f*
325.4029 266.252 m
225.3325 266.252 l
225.3325 266.7521 l
325.4029 266.7521 l
f*
426.4733 278.752 m
426.4733 266.252 l
425.9733 266.252 l
425.9733 278.752 l
f*
425.9733 266.252 m
325.9029 266.252 l
325.9029 266.7521 l
425.9733 266.7521 l
f*
527.0437 278.752 m
527.0437 266.252 l
526.5437 266.252 l
526.5437 278.752 l
f*
526.5437 266.252 m
426.4733 266.252 l
426.4733 266.7521 l
526.5437 266.7521 l
f*
575.998 266.252 m
527.0437 266.252 l
527.0437 266.7521 l
575.998 266.7521 l
f*
124.7621 266.252 m
124.7621 253.7521 l
124.2621 253.7521 l
124.2621 266.252 l
f*
124.2621 253.7521 m
35.9997 253.7521 l
35.9997 254.2521 l
124.2621 254.2521 l
f*
225.3325 266.252 m
225.3325 253.7521 l
224.8325 253.7521 l
224.8325 266.252 l
f*
224.8325 253.7521 m
124.7621 253.7521 l
124.7621 254.2521 l
224.8325 254.2521 l
f*
325.9029 266.252 m
325.9029 253.7521 l
325.4029 253.7521 l
325.4029 266.252 l
f*
325.4029 253.7521 m
225.3325 253.7521 l
225.3325 254.2521 l
325.4029 254.2521 l
f*
426.4733 266.252 m
426.4733 253.7521 l
425.9733 253.7521 l
425.9733 266.252 l
f*
425.9733 253.7521 m
325.9029 253.7521 l
325.9029 254.2521 l
425.9733 254.2521 l
f*
527.0437 266.252 m
527.0437 253.7521 l
526.5437 253.7521 l
526.5437 266.252 l
f*
526.5437 253.7521 m
426.4733 253.7521 l
426.4733 254.2521 l
526.5437 254.2521 l
f*
575.998 253.7521 m
527.0437 253.7521 l
527.0437 254.2521 l
575.998 254.2521 l
f*
124.7621 253.7521 m
124.7621 241.2522 l
124.2621 241.2522 l
124.2621 253.7521 l
f*
124.2621 241.2522 m
35.9997 241.2522 l
35.9997 241.7522 l
124.2621 241.7522 l
f*
225.3325 253.7521 m
225.3325 241.2522 l
224.8325 241.2522 l
224.8325 253.7521 l
f*
224.8325 241.2522 m
124.7621 241.2522 l
124.7621 241.7522 l
224.8325 241.7522 l
f*
325.9029 253.7521 m
325.9029 241.2522 l
325.4029 241.2522 l
325.4029 253.7521 l
f*
325.4029 241.2522 m
225.3325 241.2522 l
225.3325 241.7522 l
325.4029 241.7522 l
f*
426.4733 253.7521 m
426.4733 241.2522 l
425.9733 241.2522 l
425.9733 253.7521 l
f*
425.9733 241.2522 m
325.9029 241.2522 l
325.9029 241.7522 l
425.9733 241.7522 l
f*
527.0437 253.7521 m
527.0437 241.2522 l
526.5437 241.2522 l
526.5437 253.7521 l
f*
526.5437 241.2522 m
426.4733 241.2522 l
426.4733 241.7522 l
526.5437 241.7522 l
f*
575.998 241.2522 m
527.0437 241.2522 l
527.0437 241.7522 l
575.998 241.7522 l
f*
124.7621 241.2522 m
124.7621 228.7522 l
124.2621 228.7522 l
124.2621 241.2522 l
f*
124.2621 228.7522 m
35.9997 228.7522 l
35.9997 229.2523 l
124.2621 229.2523 l
f*
175.8781 241.2522 m
175.8781 228.7522 l
175.3781 228.7522 l
175.3781 241.2522 l
f*
175.3781 228.7522 m
124.7621 228.7522 l
124.7621 229.2523 l
175.3781 229.2523 l
f*
225.3325 241.2522 m
225.3325 228.7522 l
224.8325 228.7522 l
224.8325 241.2522 l
f*
224.8325 228.7522 m
175.8781 228.7522 l
175.8781 229.2523 l
224.8325 229.2523 l
f*
276.4485 241.2522 m
276.4485 228.7522 l
275.9485 228.7522 l
275.9485 241.2522 l
f*
275.9485 228.7522 m
225.3325 228.7522 l
225.3325 229.2523 l
275.9485 229.2523 l
f*
325.9029 241.2522 m
325.9029 228.7522 l
325.4029 228.7522 l
325.4029 241.2522 l
f*
325.4029 228.7522 m
276.4485 228.7522 l
276.4485 229.2523 l
325.4029 229.2523 l
f*
377.0189 241.2522 m
377.0189 228.7522 l
376.5189 228.7522 l
376.5189 241.2522 l
f*
376.5189 228.7522 m
325.9029 228.7522 l
325.9029 229.2523 l
376.5189 229.2523 l
f*
426.4733 241.2522 m
426.4733 228.7522 l
425.9733 228.7522 l
425.9733 241.2522 l
f*
425.9733 228.7522 m
377.0189 228.7522 l
377.0189 229.2523 l
425.9733 229.2523 l
f*
477.5893 241.2522 m
477.5893 228.7522 l
477.0893 228.7522 l
477.0893 241.2522 l
f*
477.0893 228.7522 m
426.4733 228.7522 l
426.4733 229.2523 l
477.0893 229.2523 l
f*
527.0437 241.2522 m
527.0437 228.7522 l
526.5437 228.7522 l
526.5437 241.2522 l
f*
526.5437 228.7522 m
477.5893 228.7522 l
477.5893 229.2523 l
526.5437 229.2523 l
f*
575.998 228.7522 m
527.0437 228.7522 l
527.0437 229.2523 l
575.998 229.2523 l
f*
124.7621 228.7522 m
124.7621 216.2523 l
124.2621 216.2523 l
124.2621 228.7522 l
f*
124.2621 216.2523 m
35.9997 216.2523 l
35.9997 216.7523 l
124.2621 216.7523 l
f*
175.8781 228.7522 m
175.8781 216.2523 l
175.3781 216.2523 l
175.3781 228.7522 l
f*
175.3781 216.2523 m
124.7621 216.2523 l
124.7621 216.7523 l
175.3781 216.7523 l
f*
225.3325 228.7522 m
225.3325 216.2523 l
224.8325 216.2523 l
224.8325 228.7522 l
f*
224.8325 216.2523 m
175.8781 216.2523 l
175.8781 216.7523 l
224.8325 216.7523 l
f*
276.4485 228.7522 m
276.4485 216.2523 l
275.9485 216.2523 l
275.9485 228.7522 l
f*
275.9485 216.2523 m
225.3325 216.2523 l
225.3325 216.7523 l
275.9485 216.7523 l
f*
325.9029 228.7522 m
325.9029 216.2523 l
325.4029 216.2523 l
325.4029 228.7522 l
f*
325.4029 216.2523 m
276.4485 216.2523 l
276.4485 216.7523 l
325.4029 216.7523 l
f*
377.0189 228.7522 m
377.0189 216.2523 l
376.5189 216.2523 l
376.5189 228.7522 l
f*
376.5189 216.2523 m
325.9029 216.2523 l
325.9029 216.7523 l
376.5189 216.7523 l
f*
426.4733 228.7522 m
426.4733 216.2523 l
425.9733 216.2523 l
425.9733 228.7522 l
f*
425.9733 216.2523 m
377.0189 216.2523 l
377.0189 216.7523 l
425.9733 216.7523 l
f*
477.5893 228.7522 m
477.5893 216.2523 l
477.0893 216.2523 l
477.0893 228.7522 l
f*
477.0893 216.2523 m
426.4733 216.2523 l
426.4733 216.7523 l
477.0893 216.7523 l
f*
527.0437 228.7522 m
527.0437 216.2523 l
526.5437 216.2523 l
526.5437 228.7522 l
f*
526.5437 216.2523 m
477.5893 216.2523 l
477.5893 216.7523 l
526.5437 216.7523 l
f*
575.998 216.2523 m
527.0437 216.2523 l
527.0437 216.7523 l
575.998 216.7523 l
f*
124.7621 216.2523 m
124.7621 203.7523 l
124.2621 203.7523 l
124.2621 216.2523 l
f*
124.2621 203.7523 m
35.9997 203.7523 l
35.9997 204.2524 l
124.2621 204.2524 l
f*
175.8781 216.2523 m
175.8781 203.7523 l
175.3781 203.7523 l
175.3781 216.2523 l
f*
175.3781 203.7523 m
124.7621 203.7523 l
124.7621 204.2524 l
175.3781 204.2524 l
f*
225.3325 216.2523 m
225.3325 203.7523 l
224.8325 203.7523 l
224.8325 216.2523 l
f*
224.8325 203.7523 m
175.8781 203.7523 l
175.8781 204.2524 l
224.8325 204.2524 l
f*
276.4485 216.2523 m
276.4485 203.7523 l
275.9485 203.7523 l
275.9485 216.2523 l
f*
275.9485 203.7523 m
225.3325 203.7523 l
225.3325 204.2524 l
275.9485 204.2524 l
f*
325.9029 216.2523 m
325.9029 203.7523 l
325.4029 203.7523 l
325.4029 216.2523 l
f*
325.4029 203.7523 m
276.4485 203.7523 l
276.4485 204.2524 l
325.4029 204.2524 l
f*
377.0189 216.2523 m
377.0189 203.7523 l
376.5189 203.7523 l
376.5189 216.2523 l
f*
376.5189 203.7523 m
325.9029 203.7523 l
325.9029 204.2524 l
376.5189 204.2524 l
f*
426.4733 216.2523 m
426.4733 203.7523 l
425.9733 203.7523 l
425.9733 216.2523 l
f*
425.9733 203.7523 m
377.0189 203.7523 l
377.0189 204.2524 l
425.9733 204.2524 l
f*
477.5893 216.2523 m
477.5893 203.7523 l
477.0893 203.7523 l
477.0893 216.2523 l
f*
477.0893 203.7523 m
426.4733 203.7523 l
426.4733 204.2524 l
477.0893 204.2524 l
f*
527.0437 216.2523 m
527.0437 203.7523 l
526.5437 203.7523 l
526.5437 216.2523 l
f*
526.5437 203.7523 m
477.5893 203.7523 l
477.5893 204.2524 l
526.5437 204.2524 l
f*
575.998 203.7523 m
527.0437 203.7523 l
527.0437 204.2524 l
575.998 204.2524 l
f*
124.7621 203.7523 m
124.7621 191.2524 l
124.2621 191.2524 l
124.2621 203.7523 l
f*
124.2621 191.2524 m
35.9997 191.2524 l
35.9997 191.7524 l
124.2621 191.7524 l
f*
175.8781 203.7523 m
175.8781 191.2524 l
175.3781 191.2524 l
175.3781 203.7523 l
f*
175.3781 191.2524 m
124.7621 191.2524 l
124.7621 191.7524 l
175.3781 191.7524 l
f*
225.3325 203.7523 m
225.3325 191.2524 l
224.8325 191.2524 l
224.8325 203.7523 l
f*
224.8325 191.2524 m
175.8781 191.2524 l
175.8781 191.7524 l
224.8325 191.7524 l
f*
276.4485 203.7523 m
276.4485 191.2524 l
275.9485 191.2524 l
275.9485 203.7523 l
f*
275.9485 191.2524 m
225.3325 191.2524 l
225.3325 191.7524 l
275.9485 191.7524 l
f*
325.9029 203.7523 m
325.9029 191.2524 l
325.4029 191.2524 l
325.4029 203.7523 l
f*
325.4029 191.2524 m
276.4485 191.2524 l
276.4485 191.7524 l
325.4029 191.7524 l
f*
377.0189 203.7523 m
377.0189 191.2524 l
376.5189 191.2524 l
376.5189 203.7523 l
f*
376.5189 191.2524 m
325.9029 191.2524 l
325.9029 191.7524 l
376.5189 191.7524 l
f*
426.4733 203.7523 m
426.4733 191.2524 l
425.9733 191.2524 l
425.9733 203.7523 l
f*
425.9733 191.2524 m
377.0189 191.2524 l
377.0189 191.7524 l
425.9733 191.7524 l
f*
477.5893 203.7523 m
477.5893 191.2524 l
477.0893 191.2524 l
477.0893 203.7523 l
f*
477.0893 191.2524 m
426.4733 191.2524 l
426.4733 191.7524 l
477.0893 191.7524 l
f*
527.0437 203.7523 m
527.0437 191.2524 l
526.5437 191.2524 l
526.5437 203.7523 l
f*
526.5437 191.2524 m
477.5893 191.2524 l
477.5893 191.7524 l
526.5437 191.7524 l
f*
575.998 191.2524 m
527.0437 191.2524 l
527.0437 191.7524 l
575.998 191.7524 l
f*
124.7621 191.2524 m
124.7621 178.7525 l
124.2621 178.7525 l
124.2621 191.2524 l
f*
124.2621 178.7525 m
35.9997 178.7525 l
35.9997 179.2525 l
124.2621 179.2525 l
f*
175.8781 191.2524 m
175.8781 178.7525 l
175.3781 178.7525 l
175.3781 191.2524 l
f*
175.3781 178.7525 m
124.7621 178.7525 l
124.7621 179.2525 l
175.3781 179.2525 l
f*
225.3325 191.2524 m
225.3325 178.7525 l
224.8325 178.7525 l
224.8325 191.2524 l
f*
224.8325 178.7525 m
175.8781 178.7525 l
175.8781 179.2525 l
224.8325 179.2525 l
f*
276.4485 191.2524 m
276.4485 178.7525 l
275.9485 178.7525 l
275.9485 191.2524 l
f*
275.9485 178.7525 m
225.3325 178.7525 l
225.3325 179.2525 l
275.9485 179.2525 l
f*
325.9029 191.2524 m
325.9029 178.7525 l
325.4029 178.7525 l
325.4029 191.2524 l
f*
325.4029 178.7525 m
276.4485 178.7525 l
276.4485 179.2525 l
325.4029 179.2525 l
f*
377.0189 191.2524 m
377.0189 178.7525 l
376.5189 178.7525 l
376.5189 191.2524 l
f*
376.5189 178.7525 m
325.9029 178.7525 l
325.9029 179.2525 l
376.5189 179.2525 l
f*
426.4733 191.2524 m
426.4733 178.7525 l
425.9733 178.7525 l
425.9733 191.2524 l
f*
425.9733 178.7525 m
377.0189 178.7525 l
377.0189 179.2525 l
425.9733 179.2525 l
f*
477.5893 191.2524 m
477.5893 178.7525 l
477.0893 178.7525 l
477.0893 191.2524 l
f*
477.0893 178.7525 m
426.4733 178.7525 l
426.4733 179.2525 l
477.0893 179.2525 l
f*
527.0437 191.2524 m
527.0437 178.7525 l
526.5437 178.7525 l
526.5437 191.2524 l
f*
526.5437 178.7525 m
477.5893 178.7525 l
477.5893 179.2525 l
526.5437 179.2525 l
f*
575.998 178.7525 m
527.0437 178.7525 l
527.0437 179.2525 l
575.998 179.2525 l
f*
124.7621 178.7525 m
124.7621 166.2525 l
124.2621 166.2525 l
124.2621 178.7525 l
f*
124.2621 166.2525 m
35.9997 166.2525 l
35.9997 166.7526 l
124.2621 166.7526 l
f*
175.8781 178.7525 m
175.8781 166.2525 l
175.3781 166.2525 l
175.3781 178.7525 l
f*
175.3781 166.2525 m
124.7621 166.2525 l
124.7621 166.7526 l
175.3781 166.7526 l
f*
225.3325 178.7525 m
225.3325 166.2525 l
224.8325 166.2525 l
224.8325 178.7525 l
f*
224.8325 166.2525 m
175.8781 166.2525 l
175.8781 166.7526 l
224.8325 166.7526 l
f*
276.4485 178.7525 m
276.4485 166.2525 l
275.9485 166.2525 l
275.9485 178.7525 l
f*
275.9485 166.2525 m
225.3325 166.2525 l
225.3325 166.7526 l
275.9485 166.7526 l
f*
325.9029 178.7525 m
325.9029 166.2525 l
325.4029 166.2525 l
325.4029 178.7525 l
f*
325.4029 166.2525 m
276.4485 166.2525 l
276.4485 166.7526 l
325.4029 166.7526 l
f*
377.0189 178.7525 m
377.0189 166.2525 l
376.5189 166.2525 l
376.5189 178.7525 l
f*
376.5189 166.2525 m
325.9029 166.2525 l
325.9029 166.7526 l
376.5189 166.7526 l
f*
426.4733 178.7525 m
426.4733 166.2525 l
425.9733 166.2525 l
425.9733 178.7525 l
f*
425.9733 166.2525 m
377.0189 166.2525 l
377.0189 166.7526 l
425.9733 166.7526 l
f*
477.5893 178.7525 m
477.5893 166.2525 l
477.0893 166.2525 l
477.0893 178.7525 l
f*
477.0893 166.2525 m
426.4733 166.2525 l
426.4733 166.7526 l
477.0893 166.7526 l
f*
527.0437 178.7525 m
527.0437 166.2525 l
526.5437 166.2525 l
526.5437 178.7525 l
f*
526.5437 166.2525 m
477.5893 166.2525 l
477.5893 166.7526 l
526.5437 166.7526 l
f*
575.998 166.2525 m
527.0437 166.2525 l
527.0437 166.7526 l
575.998 166.7526 l
f*
124.7621 166.2525 m
124.7621 153.7526 l
124.2621 153.7526 l
124.2621 166.2525 l
f*
124.2621 153.7526 m
35.9997 153.7526 l
35.9997 154.2526 l
124.2621 154.2526 l
f*
175.8781 166.2525 m
175.8781 153.7526 l
175.3781 153.7526 l
175.3781 166.2525 l
f*
175.3781 153.7526 m
124.7621 153.7526 l
124.7621 154.2526 l
175.3781 154.2526 l
f*
225.3325 166.2525 m
225.3325 153.7526 l
224.8325 153.7526 l
224.8325 166.2525 l
f*
224.8325 153.7526 m
175.8781 153.7526 l
175.8781 154.2526 l
224.8325 154.2526 l
f*
276.4485 166.2525 m
276.4485 153.7526 l
275.9485 153.7526 l
275.9485 166.2525 l
f*
275.9485 153.7526 m
225.3325 153.7526 l
225.3325 154.2526 l
275.9485 154.2526 l
f*
325.9029 166.2525 m
325.9029 153.7526 l
325.4029 153.7526 l
325.4029 166.2525 l
f*
325.4029 153.7526 m
276.4485 153.7526 l
276.4485 154.2526 l
325.4029 154.2526 l
f*
377.0189 166.2525 m
377.0189 153.7526 l
376.5189 153.7526 l
376.5189 166.2525 l
f*
376.5189 153.7526 m
325.9029 153.7526 l
325.9029 154.2526 l
376.5189 154.2526 l
f*
426.4733 166.2525 m
426.4733 153.7526 l
425.9733 153.7526 l
425.9733 166.2525 l
f*
425.9733 153.7526 m
377.0189 153.7526 l
377.0189 154.2526 l
425.9733 154.2526 l
f*
477.5893 166.2525 m
477.5893 153.7526 l
477.0893 153.7526 l
477.0893 166.2525 l
f*
477.0893 153.7526 m
426.4733 153.7526 l
426.4733 154.2526 l
477.0893 154.2526 l
f*
527.0437 166.2525 m
527.0437 153.7526 l
526.5437 153.7526 l
526.5437 166.2525 l
f*
526.5437 153.7526 m
477.5893 153.7526 l
477.5893 154.2526 l
526.5437 154.2526 l
f*
575.998 153.7526 m
527.0437 153.7526 l
527.0437 154.2526 l
575.998 154.2526 l
f*
124.7621 153.7526 m
124.7621 141.2527 l
124.2621 141.2527 l
124.2621 153.7526 l
f*
124.2621 141.2527 m
35.9997 141.2527 l
35.9997 141.7527 l
124.2621 141.7527 l
f*
175.8781 153.7526 m
175.8781 141.2527 l
175.3781 141.2527 l
175.3781 153.7526 l
f*
175.3781 141.2527 m
124.7621 141.2527 l
124.7621 141.7527 l
175.3781 141.7527 l
f*
225.3325 153.7526 m
225.3325 141.2527 l
224.8325 141.2527 l
224.8325 153.7526 l
f*
224.8325 141.2527 m
175.8781 141.2527 l
175.8781 141.7527 l
224.8325 141.7527 l
f*
276.4485 153.7526 m
276.4485 141.2527 l
275.9485 141.2527 l
275.9485 153.7526 l
f*
275.9485 141.2527 m
225.3325 141.2527 l
225.3325 141.7527 l
275.9485 141.7527 l
f*
325.9029 153.7526 m
325.9029 141.2527 l
325.4029 141.2527 l
325.4029 153.7526 l
f*
325.4029 141.2527 m
276.4485 141.2527 l
276.4485 141.7527 l
325.4029 141.7527 l
f*
377.0189 153.7526 m
377.0189 141.2527 l
376.5189 141.2527 l
376.5189 153.7526 l
f*
376.5189 141.2527 m
325.9029 141.2527 l
325.9029 141.7527 l
376.5189 141.7527 l
f*
426.4733 153.7526 m
426.4733 141.2527 l
425.9733 141.2527 l
425.9733 153.7526 l
f*
425.9733 141.2527 m
377.0189 141.2527 l
377.0189 141.7527 l
425.9733 141.7527 l
f*
477.5893 153.7526 m
477.5893 141.2527 l
477.0893 141.2527 l
477.0893 153.7526 l
f*
477.0893 141.2527 m
426.4733 141.2527 l
426.4733 141.7527 l
477.0893 141.7527 l
f*
527.0437 153.7526 m
527.0437 141.2527 l
526.5437 141.2527 l
526.5437 153.7526 l
f*
526.5437 141.2527 m
477.5893 141.2527 l
477.5893 141.7527 l
526.5437 141.7527 l
f*
575.998 141.2527 m
527.0437 141.2527 l
527.0437 141.7527 l
575.998 141.7527 l
f*
124.7621 141.2527 m
124.7621 128.7527 l
124.2621 128.7527 l
124.2621 141.2527 l
f*
124.2621 128.7527 m
35.9997 128.7527 l
35.9997 129.2528 l
124.2621 129.2528 l
f*
175.8781 141.2527 m
175.8781 128.7527 l
175.3781 128.7527 l
175.3781 141.2527 l
f*
175.3781 128.7527 m
124.7621 128.7527 l
124.7621 129.2528 l
175.3781 129.2528 l
f*
225.3325 141.2527 m
225.3325 128.7527 l
224.8325 128.7527 l
224.8325 141.2527 l
f*
224.8325 128.7527 m
175.8781 128.7527 l
175.8781 129.2528 l
224.8325 129.2528 l
f*
276.4485 141.2527 m
276.4485 128.7527 l
275.9485 128.7527 l
275.9485 141.2527 l
f*
275.9485 128.7527 m
225.3325 128.7527 l
225.3325 129.2528 l
275.9485 129.2528 l
f*
325.9029 141.2527 m
325.9029 128.7527 l
325.4029 128.7527 l
325.4029 141.2527 l
f*
325.4029 128.7527 m
276.4485 128.7527 l
276.4485 129.2528 l
325.4029 129.2528 l
f*
377.0189 141.2527 m
377.0189 128.7527 l
376.5189 128.7527 l
376.5189 141.2527 l
f*
376.5189 128.7527 m
325.9029 128.7527 l
325.9029 129.2528 l
376.5189 129.2528 l
f*
426.4733 141.2527 m
426.4733 128.7527 l
425.9733 128.7527 l
425.9733 141.2527 l
f*
425.9733 128.7527 m
377.0189 128.7527 l
377.0189 129.2528 l
425.9733 129.2528 l
f*
477.5893 141.2527 m
477.5893 128.7527 l
477.0893 128.7527 l
477.0893 141.2527 l
f*
477.0893 128.7527 m
426.4733 128.7527 l
426.4733 129.2528 l
477.0893 129.2528 l
f*
527.0437 141.2527 m
527.0437 128.7527 l
526.5437 128.7527 l
526.5437 141.2527 l
f*
526.5437 128.7527 m
477.5893 128.7527 l
477.5893 129.2528 l
526.5437 129.2528 l
f*
575.998 128.7527 m
527.0437 128.7527 l
527.0437 129.2528 l
575.998 129.2528 l
f*
575.998 95.0026 m
35.9997 95.0026 l
35.9997 95.5026 l
575.998 95.5026 l
f*
0 g
36 318.274 m
47.2819 318.274 l
47.2819 317.7638 l
36 317.7638 l
f*
36 280.2331 m
92.9197 280.2331 l
92.9197 279.7795 l
36 279.7795 l
f*
0.83 0.64 0.02 0 k
36 81.9213 m
186.7465 81.9213 l
h
f*
0 g
7.9999 0 0 7.9999 36 360.1133 cm
BT
/F11 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.5512 0 Td
(1.)Tj
1.1763 0 Td
(Demographi)Tj
5.2583 0 Td
(c)Tj
0.6378 0 Td
(characterist)Tj
4.8828 0 Td
(ics)Tj
1.311 0 Td
(and)Tj
1.7788 0 Td
(working)Tj
3.6425 0 Td
(memory)Tj
3.6992 0 Td
(performan)Tj
4.4717 0 Td
(ce)Tj
1.0772 0 Td
(\(Discover)Tj
3.9898 0 Td
(y)Tj
0.6874 0 Td
(sample\).)Tj
0 Tc
-20.2891 -1.8567 Td
(All)Tj
1.4953 0 Td
(Subjects)Tj
12.2032 0 Td
(Urban)Tj
12.7135 0 Td
(Town)Tj
12.6001 0 Td
(Rural)Tj
-38.5231 -1.559 Td
(\(N)Tj
1.3181 0 Td
(=)Tj
0.8008 0 Td
(124\))Tj
10.7008 0 Td
(\(N)Tj
1.3252 0 Td
(=)Tj
0.8008 0 Td
(28\))Tj
10.4458 0 Td
(\(N)Tj
1.3252 0 Td
(=)Tj
0.8008 0 Td
(66\))Tj
10.4457 0 Td
(\(N)Tj
1.3182 0 Td
(=)Tj
0.8078 0 Td
(30\))Tj
-55.4531 -1.5591 Td
(Sex)Tj
0.9992 -1.6299 Td
(Male)Tj
/F6 1 Tf
15.8741 0 Td
(56)Tj
12.5718 0 Td
(15)Tj
12.5717 0 Td
(31)Tj
12.5718 0 Td
(10)Tj
/F11 1 Tf
-53.5894 -1.5662 Td
(Female)Tj
/F6 1 Tf
15.8741 0 Td
(68)Tj
12.5718 0 Td
(13)Tj
12.5717 0 Td
(35)Tj
12.5718 0 Td
(20)Tj
/F12 1 Tf
-54.5886 -1.559 Td
[()-6()13()]TJ
/F11 1 Tf
3.0756 0 Td
(Genotyp)Tj
3.6 0 Td
(e)Tj
-5.6764 -1.63 Td
(Val/Val)Tj
/F6 1 Tf
15.8741 0 Td
(22)Tj
12.8056 0 Td
(5)Tj
12.3379 0 Td
(15)Tj
12.8056 0 Td
(2)Tj
/F11 1 Tf
-53.8232 -1.559 Td
(Val/Me)Tj
3.0898 0 Td
(t)Tj
/F6 1 Tf
12.7843 0 Td
(60)Tj
12.5718 0 Td
(12)Tj
12.5717 0 Td
(30)Tj
12.5718 0 Td
(18)Tj
/F11 1 Tf
-53.5894 -1.5662 Td
(Met/Met)Tj
/F6 1 Tf
15.8741 0 Td
(42)Tj
12.5718 0 Td
(11)Tj
12.5717 0 Td
(21)Tj
12.5718 0 Td
(10)Tj
/F11 1 Tf
-41.5067 -1.5591 Td
(Mean)Tj
6.8316 0 Td
(SD)Tj
5.7402 0 Td
(Mean)Tj
6.8315 0 Td
(SD)Tj
5.7402 0 Td
(Mean)Tj
6.8316 0 Td
(SD)Tj
5.7402 0 Td
(Mean)Tj
6.8316 0 Td
(SD)Tj
6.5126 0 Td
(P)Tj
-64.1414 -1.5661 Td
(Age)Tj
1.8567 0 Td
(\(years\))Tj
/F6 1 Tf
11.5725 0 Td
(31.9)Tj
6.5268 0 Td
(8.9)Tj
6.0449 0 Td
(31.5)Tj
6.5198 0 Td
(9.3)Tj
6.052 0 Td
(32.4)Tj
6.5197 0 Td
(9.0)Tj
6.052 0 Td
(31.1)Tj
6.5198 0 Td
(8.4)Tj
6.0945 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.5591 Td
(Education)Tj
4.5212 0 Td
(\(years\))Tj
/F6 1 Tf
8.908 0 Td
(17.3)Tj
6.5268 0 Td
(2.3)Tj
6.0449 0 Td
(17.3)Tj
6.5198 0 Td
(1.4)Tj
6.052 0 Td
(16.8)Tj
6.5197 0 Td
(2.4)Tj
6.052 0 Td
(18.4)Tj
6.5198 0 Td
(2.5)Tj
5.7048 0 Td
(0.007)Tj
/F11 1 Tf
-63.369 -1.5661 Td
(SES)Tj
/F6 1 Tf
13.4292 0 Td
(51.6)Tj
6.5268 0 Td
(8.9)Tj
6.0449 0 Td
(53.4)Tj
6.5198 0 Td
(7.5)Tj
6.052 0 Td
(50.9)Tj
6.5197 0 Td
(9.4)Tj
6.052 0 Td
(51.7)Tj
6.5198 0 Td
(9.0)Tj
6.0945 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.5591 Td
(Childhoo)Tj
3.9331 0 Td
(d)Tj
0.7795 0 Td
(SES)Tj
/F6 1 Tf
8.7166 0 Td
(51.7)Tj
6.2859 0 Td
(11.5)Tj
6.2858 0 Td
(54.6)Tj
6.5198 0 Td
(9.8)Tj
6.052 0 Td
(50.5)Tj
6.2859 0 Td
(11.5)Tj
6.2858 0 Td
(51.9)Tj
6.2859 0 Td
(12.7)Tj
6.3284 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.5662 Td
(WAIS-IQ)Tj
/F6 1 Tf
13.1882 0 Td
(112.1)Tj
6.7678 0 Td
(9.1)Tj
5.804 0 Td
(111.6)Tj
6.7607 0 Td
(9.4)Tj
5.811 0 Td
(111.9)Tj
6.7607 0 Td
(9.1)Tj
5.8111 0 Td
(113.1)Tj
6.7607 0 Td
(9.3)Tj
6.0945 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.559 Td
(Handedne)Tj
4.337 0 Td
(ss)Tj
/F6 1 Tf
9.0922 0 Td
(75.0)Tj
6.2859 0 Td
(45.5)Tj
6.2858 0 Td
(59.6)Tj
6.2859 0 Td
(63.5)Tj
6.2859 0 Td
(83.7)Tj
6.2859 0 Td
(25.4)Tj
6.2858 0 Td
(70.3)Tj
6.2859 0 Td
(56.2)Tj
6.3284 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.5662 Td
(2-Back)Tj
3.1039 0 Td
(%)Tj
0.9921 0 Td
(Correct)Tj
/F6 1 Tf
9.3332 0 Td
(78.7)Tj
6.2859 0 Td
(16.2)Tj
6.2858 0 Td
(76.5)Tj
6.2859 0 Td
(14.3)Tj
6.2859 0 Td
(78.1)Tj
6.2859 0 Td
(16.9)Tj
6.2858 0 Td
(81.8)Tj
6.2859 0 Td
(16.6)Tj
6.3284 0 Td
(n.s.)Tj
/F11 1 Tf
-63.7587 -1.5591 Td
(2-Back)Tj
3.1039 0 Td
(RT)Tj
1.5307 0 Td
(\(msec\))Tj
/F6 1 Tf
8.5536 0 Td
(522.5)Tj
6.2859 0 Td
(286.3)Tj
6.2859 0 Td
(509.1)Tj
6.2859 0 Td
(346.2)Tj
6.2858 0 Td
(523.5)Tj
6.2859 0 Td
(265.2)Tj
6.2859 0 Td
(532.5)Tj
6.2859 0 Td
(281.7)Tj
6.5693 0 Td
(n.s.)Tj
-63.7587 -2.3456 Td
(Demograp)Tj
4.2874 0 Td
(hic)Tj
1.4598 0 Td
(differenc)Tj
3.5788 0 Td
(es)Tj
1.0205 0 Td
(across)Tj
2.7 0 Td
(urbanicity)Tj
4.3512 0 Td
(categories)Tj
4.2308 0 Td
(at)Tj
0.9638 0 Td
(discovery.)Tj
4.2732 0 Td
(Significan)Tj
4.004 0 Td
(t)Tj
0.5315 0 Td
(differences)Tj
4.6063 0 Td
(are)Tj
1.4599 0 Td
(denoted)Tj
3.5008 0 Td
(by)Tj
1.1976 0 Td
(p)Tj
0.7512 0 Td
(values.)Tj
2.9197 0 Td
(Abbrevi)Tj
3.2245 0 Td
(ations:)Tj
2.8913 0 Td
(SES)Tj
1.7575 0 Td
(=)Tj
0.8079 0 Td
(socioeconomic)Tj
6.2434 0 Td
(status,)Tj
-60.7611 -1.4953 Td
(WAIS-IQ)Tj
4.1457 0 Td
(=)Tj
0.8078 0 Td
(Wechsler)Tj
3.9898 0 Td
(Adult)Tj
2.53 0 Td
(Intellig)Tj
2.8488 0 Td
(ence)Tj
2.0622 0 Td
(ScaleIn)Tj
3.8268 0 Td
(telligence)Tj
4.0253 0 Td
(Quotient,)Tj
4.089 0 Td
(handedness)Tj
4.9394 0 Td
(as)Tj
1.0275 0 Td
(measured)Tj
4.1316 0 Td
(by)Tj
1.1976 0 Td
(the)Tj
1.4882 0 Td
(Edinburgh)Tj
4.5568 0 Td
(Handednes)Tj
4.5779 0 Td
(s)Tj
0.5953 0 Td
(Inventory,)Tj
4.4292 0 Td
(n.s.)Tj
1.5945 0 Td
(=)Tj
0.815 0 Td
(non-signifi)Tj
4.4433 0 Td
(cant.)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.025 Tc
-62.1217 -2.2536 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0195189.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 364.9889 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Urbanicity)Tj
4.585 0 Td
(and)Tj
1.8496 0 Td
(dopamine)Tj
4.5355 0 Td
(gene)Tj
2.4024 0 Td
(interacti)Tj
3.4299 0 Td
(ons)Tj
1.8071 0 Td
(on)Tj
1.3111 0 Td
(fMRI)Tj
2.3031 0 Td
(activation)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01951)Tj
4.089 0 Td
(89)Tj
0 g
2.0906 0 Td
(April)Tj
2.1827 0 Td
(10,)Tj
1.5874 0 Td
(2018)Tj
35.1357 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
111 0 obj
<>stream
endstream
endobj
112 0 obj
<>stream
endstream
endobj
113 0 obj
<>stream
endstream
endobj
114 0 obj
<>stream
endstream
endobj
115 0 obj
<>stream
endstream
endobj
116 0 obj
<>stream
endstream
endobj
117 0 obj
<>stream
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
BT
66.402 0 Td
(20)Tj
ET
Q
endstream
endobj
124 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 128 0 R/Contents 129 0 R/TrimBox[0 0 612 792]>>
endobj
125 0 obj
<>
endobj
130 0 obj
<>
endobj
131 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Symbols def
/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 128 /ff put
dup 129 /ffi put
dup 130 /ffl put
dup 131 /C131 put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 138 /C138 put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤(HwK7X7
Mr:E%]3<Ӝ$wrAQ4ADt%̏>E hAجm*pu@>#6aZi}NRmƼ%
,OgX' EX?ڞ\#JEG<IXS}Eh[ş8ї48ٶ.w4bJ?_nfulqD?둓\C%+' { L9K7isW+ӕ(6oɧVҺlS;5K
Z%.oQՕW*9Qk_S+B-}%lYC@WP0b\KKdi>t,n_S[ '9`-z+cڦEb#c@;yɸoAT O_H~i -6ϰ豟Ae&BF+
wNX!=hhUF8(hZ6pgJc m'9dx*^wXc
գ<.쯶c ln)/LvXY2jbF:ȸ3'>\Ȥmzj,!:ZK' (q/ -&&S ؤ-bm KQSxLGu `D3yԱKaVMU§ %iq5%s 2SdR#ho45H.4TdՊa<K>BqG- Ao, (e&F2gG`z8*༠&
x#B
B;8!93~T/ \>nLazCSKm~,!_<ӾX@X@N2vEt בFmBYa wRG[i;+oM+%(8 jԀlIW>t